nonclinical safety assessment Bouchard, Page R. editor. Sahota, Pritam S. editor. Wallace, Shannon editor. Wojcinski, Zbigniew W. editor. Schumacher, Vanessa L. editor. Sabio, David A. illustrator. text nyu New York CRC Press c2025 2025 Third edition. monographic eng

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xv, 818 p. : illas. ; 26 cm. "The new edition provides practical and timely information for toxicologic pathologists working in drug discovery and development. The introductory concept chapters are consolidated into two more concise and better organized introductory chapters. The two concept chapters introduce the reader to pharmaceutical R&D, the role of the pathologist in the process, and critical partner scientific disciplines with whom the pathologist will collaborate. In this revision, the organ system chapters incorporate more consistent commentary and guidance on the molecular mechanism of action, human translational relevance, and regulatory impact of pathological findings as they are described in these chapters"-- Nonclinical Safety Assessment : An Overview of Drug and Medical Device Development / Thomas M. Monticello, Timothy MacLachlan, Kathleen A. Funk, Brooke M. Rock, Jeanine L. Bussiere, Jessica Grieves, JoAnne C.L. Schuh, and Scott Henry -- Toxicologic Anatomic Pathology and the Pathologist / Vanessa L. Schumacher, Christopher J. Clarke, Robert C. Johnson, Arun R. Pandiri, and Daniel J. Patrick -- Toxicologic Clinical Pathology / Niraj K. Tripathi -- Gastrointestinal System / Thomas Nolte, Jagannatha Mysore, Arlin Rogers, and Johannes Junginger -- Hepatobiliary System and Exocrine Pancreas / Arun R. Pandiri, Barbara Lenz, and Christopher D. Houle -- Respiratory System / Tom P. McKevitt and Nicholas Macri -- Urinary System / Kendall S. Frazier and John Curtis Seely -- Hematopoietic System / Kristin L. Henson, Tanasa S. Osborne, Allison Vitsky, and Adi Wasserkrug-Naor -- Lymphoid System / Patrick Haley -- Musculoskeletal System and Teeth / Kathryn E. Gropp, Agathe Bédard, Stacey Fossey, D. Greg Hall, and Ryan M. Schafbuch -- Cardiovascular System / Ronnie Chamanza, Chidozie Amuzie, David Brott, and Calvert Louden -- Endocrine System / Richard A. Peterson, Christopher Houle, and Raju Mantena -- Reproductive System and Mammary Gland / Justin D. Vidal, Sarah Coe, Karyn Colman, Kiran Palyada, Cynthia J. Willson, and Charles E. Wood -- Integumentary System / Zbigniew W. Wojcinski, Lydia Andrews-Jones, Daher Ibrahim Aibo, Rie Kikkawa, Sheila Cummings, and Robert Dunstan -- Nervous System / Sarah D. Cramer, Alys Bradley, and Mark T. Butt -- Special Senses : Eye and Ear / Vanessa Vrolyk, Kenneth A. Schafer, Oliver C. Turner, Helen S. Booler, and Richard A. Altschuler. edited by Page Bouchard, Pritam Sahota, Shannon Wallace, Zbigniew Wojcinski, and Vanessa Schumacher ; illustrated by David A. Sabio. Includes bibliographical references and index. Drug Evaluation, Preclinical Risk Assessment Toxicity Tests 615.9 BOT 9781032319193 9781032319223 BD-ChVAS 260723 20260723100615.0 eng