technologies and innovations Tay, Andy Kah Ping creator text New York CRC Press c2025 First edition. monographic eng

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vii, 111 p. : ill., table ; 22 cm . "This edited volume describes innovations in all steps of the CAR-T manufacturing chain. These vital descriptions will help practitioners to overcome current challenges during the process and vastly reduce costs and enable timely and accessible administration of CAR-T therapy to patients. The book provides readers with information on key fundamental concepts of CAR-T manufacturing in areas such as cell selection, cell activation, cell transfection, cell expansion, genetic engineering, and quality control. In each chapter, different experts cover a particular technological field in the CAR-T manufacturing chain. Each chapter will include an introduction to the importance of a particular technology for cell manufacturing, comparisons of state-of-the-art methods, and discussions on emerging innovations of that particular technology. This exposes readers to a high-level view of the entire process while diving into details for each specific process step. Readers will be able to apply their knowledge to make changes at each step of the CAR-T manufacturing process to reduce the currently high costs and long production times, so that cancer patients globally can benefit from CAR-T therapy. This book is an invaluable resource for practitioners in CAR-T manufacturing who aim to improve their quality and efficiency while reducing time and costs. It is also useful for advanced undergraduate and graduate students who wish to gain a strong foundation for continuing research in the field or interacting with practitioners"-- Immune cell selection and Isolation / Jessalyn Low, Andy Tay -- Strategies for T cell Activation / Jessalyn Low, Andy Tay -- Genetic tools to engineer CAR-T cells : Lessons from clinical studies / Yu Yang Ng, Andy Tay -- Intracellular delivery methods for therapeutic immune T-cell engineering / Arun R. K. Kumar, Andy Tay -- Bioreactor technology for CAR T cell manufacturing / Yi Kai Luo, Andy Tay -- Quality Control of CAR-T Products / Jerome Adriel Tjiptadi, Andy Tay -- Advances for in vivo CAR-T manufacturing / Mohamed Bilal S/O Saibudeen, Kenneth Goh Jun Lim, Andy Tay. edited by Andy Kah Ping Tay. Includes bibliographical references and index. Immunotherapy, Adoptive methods Cell Engineering methods 616.0277 TAC 9781032660769 9781032660738 BD-ChVAS 260709 20260709131035.0 eng